The Pennines (), also known as the Pennine Chain or Pennine Hills, are a range of uplands running between three regions of Northern England: North West England on the west, North East England and Yorkshire and the Humber on the east. Commonly described as the "backbone of England", the range stretches northwards from the Peak District at the southern end, through the South Pennines, Yorkshire Dales and North Pennines to the Tyne Gap, which separates the range from the Border Moors and Cheviot Hills across the Anglo-Scottish border, although some definitions include them. South of the Aire Gap is a western spur into east Lancashire, comprising the Rossendale Fells, West Pennine Moors and the Bowland Fells in North Lancashire. The Howgill Fells and Orton Fells in Cumbria are sometimes considered to be Pennine spurs to the west of the range. The Pennines are an important water catchment area with numerous reservoirs in the head streams of the river valleys.

The North Pennines and Nidderdale are designated Areas of Outstanding Natural Beauty (AONB), as are Bowland and Pendle Hill. Parts of the Pennines are incorporated into the Peak District National Park and Yorkshire Dales National Park. Britain's oldest long-distance footpath, the 268-mile (429 km) Pennine Way, runs along most of the Pennine Chain.